Pluryal Classic
Composition: 25 mg/ml cross-linked hyaluronic acid, phosphate buffer, NaCl
A professional, in-depth guide about compositions, structural differences, and indication areas.

Composition: 25 mg/ml cross-linked hyaluronic acid, phosphate buffer, NaCl
Composition: 25 mg/ml cross-linked hyaluronic acid, phosphate buffer, NaCl
Composition: high-viscosity cross-linked HA, phosphate buffer, NaCl
The base is a 25 mg/ml concentration of cross-linked hyaluronic acid gel, composed of a blend of two HA chains with different molecular weights (1 MDa and 2 MDa). This is complemented by an outer layer of free HA with a molecular weight of 500 kDa, which protects the HA against enzymatic degradation. A distinctive feature of the technology is the three-dimensional matrix, produced at low temperatures with extended cross-linking time. As a result, the products achieve an extremely low residual BDDE level of <0.1 ppm.
Composition:
25 mg/ml hyaluronic acid → 7% free HA
Two types of cross-linked HA: 1M and 2M Da
Phosphate buffer
NaCl
Composition:
25 mg/ml hyaluronic acid → 5% free HA
Two types of cross-linked HA: 1M and 2M Da (with higher G’ value)
Phosphate buffer
NaCl
Composition:
25 mg/ml hyaluronic acid → 10% free HA
Three molecular weights of HA: 2M, 1M, 500 kDa
Phosphate buffer
Pluryal’s patented HPN Technology uses purified, sterile polynucleotides as its main active ingredient, derived from salmon milt. The resulting substance is biocompatible, of natural origin, and fully biodegradable in tissue. Through its mechanism of action, it enhances fibroblast activity, improves skin hydration levels, stimulates collagen production, increases tissue oxygenation and skin elasticity, while also promoting DNA regeneration. The result is a comprehensive, multi-level skin rejuvenation and tissue regeneration process.
Composition:
Polynucleotide (PN): 20 mg / 2 ml
Hyaluronic acid (free): 20 mg / 2 ml (10 mg/ml)
Mannitol: 80 mg / 2 ml (40 mg/ml)
Composition:
High-purity polynucleotide: 15 mg / 2 ml (7.5 mg/ml)
Phosphate buffer
Composition:
Polynucleotides (purified DNA fractions of salmon milt origin)

| Area | Recommended Pluryal products |
|---|---|
| Periorbital area | Pluryal Silk |
| Lips / perioral area | Pluryal Classic, Pluryal Silk, Pluryal Densify |
| Nasolabial fold | Pluryal Classic, Pluryal Volume |
| Marionette lines | Pluryal Classic, Pluryal Volume |
| Mid-face / cheeks / zygomatic area | Pluryal Volume, Pluryal BioVolume, Pluryal BioClassic, Pluryal Densify |
| Chin | Pluryal Contour, Pluryal Volume, Pluryal BioSculpture |
| Jawline / mandible | Pluryal Contour, Pluryal BioSculpture, Pluryal Volume |
| Facial oval / loss of contour | Pluryal BioSculpture, Pluryal BioVolume, Pluryal Contour |
| Full face – skin quality improvement | Pluryal Densify, Pluryal Silk, Pluryal BioClassic |
| Neck | Pluryal BioClassic, Pluryal Densify, Pluryal BioVolume, Pluryal Silk |
| Décolletage | Pluryal BioClassic, Pluryal Densify |
| Hands | Pluryal Densify, Pluryal BioClassic |
| Scalp (hair) | Pluryal Hair Density |
| Product | Target concern | Facial/body area |
|---|---|---|
| Pluryal Classic | Moderate wrinkles, minor volume loss | Lips, nasolabial fold, marionette lines, perioral area |
| Pluryal Volume | Deep volume loss, restoration of facial fullness | Zygomatic arch, cheeks, chin, jawline, mid-face |
| Pluryal Contour | Contour definition, profile reshaping | Jawline, chin tip, facial contour |
| Pluryal BioClassic | Mild to moderate laxity, loss of elasticity | Full face, neck, décolletage |
| Pluryal BioVolume | Significant sagging, volume loss | Mid-face, contours, zygomatic arch, chin |
| Pluryal BioSculpture | Loose contours, sagging facial oval | Jawline, mandible, facial oval |
| Pluryal Densify | Thin, toneless, weakened skin | Full face, perioral area, neck, hands |
| Pluryal Silk | Fine lines, texture improvement, periocular lines | Eye contour, lip area, delicate zones |
| Pluryal Hair Density | Hair loss, thinning | Scalp, hairline, crown area |
| Product | Type | Indication | Key ingredients / main feature |
|---|---|---|---|
| Pluryal Classic | Filler | Moderate wrinkles, minor volume loss, lips | Cross-linked hyaluronic acid 25 mg/ml |
| Pluryal Volume | Filler | Deep volume loss | Cross-linked hyaluronic acid 25 mg/ml (high viscosity) |
| Pluryal Contour | Filler | Contour definition, profile reshaping | High-density, high-viscosity cross-linked HA |
| Pluryal BioClassic | Biofiller | Moderate volume loss + skin structure improvement | 25 mg/ml HA (7% free HA), phosphate buffer, NaCl |
| Pluryal BioVolume | Biofiller | Severe volume loss | 25 mg/ml HA (5% free HA), phosphate buffer, NaCl |
| Pluryal BioSculpture | Bio-densifier | Remodelling, contours, facial oval | 25 mg/ml HA (10% free HA), three HA molecular weights |
| Pluryal Densify | PN biostimulator | Skin density, regeneration | PN 20 mg + free HA 20 mg + Mannitol 80 mg / 2 ml |
| Pluryal Silk | PN biostimulator | Delicate areas (eyes, lips), texture improvement | High-purity PN 15 mg / 2 ml |
| Pluryal Hair Density | PN biostimulator | Hair loss, scalp regeneration | High-purity polynucleotides (salmon milt origin) |
Personalize your treatments with the power of the Pluryal range
View all Pluryal products →